© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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BP, use-dependent sodium channel blocker
Ph. II oral efficacy in trigeminal neuralgia
from cell-based HTS and ligand-based opt.
ACS Med. Chem. Lett., Jul. 16, 2020
biogen / Convergence / GSK, MA / UK
Vixotrigine (BIIB074) is a voltage-gated sodium channel blocker that preferentially binds to the inactivated state of the sodium channels, conferring selectivity for channels involved in pain-associated high frequency nerve signalling…
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