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Sep. 18, 2021

Vixotrigine: A Voltage-Gated Sodium Channel Blocker

Vixotrigine (BIIB074)

BP, use-dependent sodium channel blocker Ph. II oral efficacy in trigeminal neuralgia from cell-based HTS and ligand-based opt. ACS Med. Chem. Lett., Jul. 16, 2020 biogen / Convergence / GSK, MA / UK

Drug Hunter Team

Vixotrigine (BIIB074) is a voltage-gated sodium channel blocker that preferentially binds to the inactivated state of the sodium channels, conferring selectivity for channels involved in pain-associated high frequency nerve signalling over normal low frequency nerve signalling (use-/state-dependence). The use-dependent activity is believed to [...]



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