BP, use-dependent sodium channel blocker

Ph. II oral efficacy in trigeminal neuralgia

from cell-based HTS and ligand-based opt.

ACS Med. Chem. Lett., Jul. 16, 2020

biogen / Convergence / GSK, MA / UK

Structure of Vixotrigine (BIIB074), a voltage- and use-dependent sodium channel blocker

Vixotrigine (BIIB074) is a voltage-gated sodium channel blocker that preferentially binds to the inactivated state of the sodium channels, conferring selectivity for channels involved in pain-associated high frequency nerve signalling…


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