non-nucleoside STING agonist

single agent systemic activity in I/O model

from 100k cmpd cellular pheno. screen + opt.

Science, Aug. 21, 2020

TSRI / Calibr, La Jolla, CA

Structure of non-nucleotide STING agonist SR-717

SR-717 is STING agonist with a surprisingly similar mechanism to MSA-2, published contemporaneously with MSA-2. The identification of a second carboxylic acid-type molecule with both 2:1 binding stoichiometry and apparent…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: