non-nucleoside STING agonist

single agent systemic activity in I/O model

from 100k cmpd cellular pheno. screen + opt.

Science, Aug. 21, 2020

TSRI / Calibr, La Jolla, CA

Structure of non-nucleotide STING agonist SR-717

SR-717 is STING agonist with a surprisingly similar mechanism to MSA-2, published contemporaneously with MSA-2. The identification of a second carboxylic acid-type molecule with both 2:1 binding stoichiometry and apparent…

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