non-nucleoside STING agonist
single agent systemic activity in I/O model
from 100k cmpd cellular pheno. screen + opt.
Science, Aug. 21, 2020
TSRI / Calibr, La Jolla, CA
SR-717
1 min read
SR-717 is STING agonist with a surprisingly similar mechanism to MSA-2, published contemporaneously with MSA-2. The identification of a second carboxylic acid-type molecule with both 2:1 binding stoichiometry and apparent tumor selectivity support both papers’ MoA hypotheses.
Search By Structure
- GS-6207
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- MSA-2
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