1 minute read
Dec. 10, 2021

Reldesemtiv: A Second Generation Troponin Activator


second gen. oral troponin activator Ph. III candidate for ALS (300 mg BID) from HTS in muscle assay and reducing BP Journal of Medicinal Chemistry Cytokinetics, South San Francisco, CA

Drug Hunter Team

The Cytokinetics second generation troponin activator, reldesemtiv , is intended to treat muscle weakness by directly activating skeletal muscle. A high concentration of free drug is expected to be needed due to the large amount of fast skeletal muscle troponin in the body, making safety and selectivity critical. Reldesemtiv demonstrated [...]



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