oral non-nucleoside STING agonist

single agent systemic activity in I/O model

from 2.4M cmpd cell-based phenotypic screen

Science, Aug. 21, 2020

Merck & Co., Kenilworth, NJ

MSA-2 is an orally available agonist of the STING protein, which potently induces inflammation. Clinically evaluated cyclic dinucleotide-based STING agonists have typically been dosed intratumorally to promote anti-tumor inflammation but…


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