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oral non-nucleoside STING agonist
single agent systemic activity in I/O model
from 2.4M cmpd cell-based phenotypic screen
Science, Aug. 21, 2020
Merck & Co., Kenilworth, NJ
MSA-2 is an orally available agonist of the STING protein, which potently induces inflammation. Clinically evaluated cyclic dinucleotide-based STING agonists have typically been dosed intratumorally to promote anti-tumor inflammation but…
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