oral non-nucleoside STING agonist

single agent systemic activity in I/O model

from 2.4M cmpd cell-based phenotypic screen

Science, Aug. 21, 2020

Merck & Co., Kenilworth, NJ

Structure of non-nucleotide STING agonist MSA-2

MSA-2 is an orally available agonist of the STING protein, which potently induces inflammation. Clinically evaluated cyclic dinucleotide-based STING agonists have typically been dosed intratumorally to promote anti-tumor inflammation but…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: