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Apr. 2, 2024
MK-1084: A Macrocyclic KRAS(G12C) Inhibitor from Merck
MK-1084
oral covalent KRAS(G12C) mutant-selective inhibitor Ph. I for solid tumors as monotherapy/combination with pembrolizumab Structure-informed optimization from Amgen’s sotorasib ACS Spring 2024 meeting presentation Merck/Taiho/Astex