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Dec. 10, 2021

JNJ-A07: A Pan-Genotype, Pan-Serotype Dengue Virus Inhibitor


pan-genotype, pan-serotype dengue virus inh. high barrier to resistance, efficacious in vivo from phenotypic antiviral screen Nature Janssen Pharmaceutica, Beerse, BE

Drug Hunter Team

The Janssen pan-genotype, pan-serotype dengue virus inhibitor, JNJ-A07 , demonstrates broad activity against a panel of 21 clinical isolates and has a high barrier to resistance. It blocks the interaction between the non-enzymatic NS4B protein and NS3, preventing them from forming an NS3-NS4B complex which is essential for replication (though [...]



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