BMS-986120
oral PAR4 antagonist Ph. II completed in thrombosis (discontinued) HTS, potency, and PK opt. J. Med. Chem. Bristol-Myers Squibb, Princeton, NJ
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The Merck CETP inhibitor backup, MK-8262 , is potential best-in-class CETP inhibitor, which was only discontinued as a backup due to the success of its predecessor, anacetrapib in Ph. III. Reviewer Kim Huard thought this CETP inhibitor was a great piece of work from Merck, and is a great example how to deal with a very lipophilic binding site [...]
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