4 minute read
Oct. 29, 2022

ICeD-2: a Dipeptidyl Peptidase 9 (DPP9) Inhibitor for HIV-1 Infections


oral DPP9 inhibitor in vitro synergy with NNRTI for HIV from 250k cmpd phenotypic screen ACS Chem. Biol., Aug 31, 2022 Merck, Rahway, NJ

Drug Hunter Team

ICeD-2 (Merck) is a dipeptidyl peptidase 9 (DPP9) inhibitor under development for HIV-1 infections. Despite the significant advancements in antiretroviral therapy research leading to the approval of some highly effective treatments , the cure for HIV-1 infection has been elusive. A phenotypic screen looking at compound-induced HIV-1 [...]



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