oral DPP9 inhibitor
in vitro synergy with NNRTI for HIV
from 250k cmpd phenotypic screen
ACS Chem. Biol.
Merck, Rahway, NJ
Context. ICeD-2 (Merck) is a dipeptidyl peptidase 9 (DPP9) inhibitor under development for HIV-1 infections. Despite the significant advancements in antiretroviral therapy research leading to the approval of some…