3 minute read
Dec. 28, 2022

Squalamine: a Potential Parkinson’s Treatment


oral ⍺-synuclein aggregation inhibitor completed Ph. IIb for PD + constipation natural product Sci. Adv., 16 November 2022 Enterin Inc., Philadelphia, PA

Drug Hunter Team

An old molecule and an old target come together. Squalamine was originally discovered in 1993 as an antimicrobial from the liver of the dogfish shark. It’s had a long and interesting history, investigated by Magainin/Genaera as a Ph. II antiangiogenic drug candidate for cancer and as a Ph. III opthalmic candidate for macular degeneration. One [...]



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