potent oral non-_-opioid receptor analgesic
oral activity in pain model, unknown mech.
Inspired by natural product, conolidine
Bioorg. Med. Chem., Aug. 8, 2020
Daiichi Sankyo, Tokyo, JP
DS34942424
1 min read
DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able to demonstrate that the compound does not exert its activity through the mu-opioid receptor, the mechanism of action is not understood. The identification of non-opioid analgesics are an area of intense interest and hopefully we will learn how this compound works in the near future.
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