molecules of the month


potent oral non-_-opioid receptor analgesic

oral activity in pain model, unknown mech.

Inspired by natural product, conolidine

Bioorg. Med. Chem., Aug. 8, 2020

Daiichi Sankyo, Tokyo, JP

Structure of DS34942424, an orally potent analgesic without mu opioid receptor agonist activity
1 min read

DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able to demonstrate that the compound does not exert its activity through the mu-opioid receptor, the mechanism of action is not understood. The identification of non-opioid analgesics are an area of intense interest and hopefully we will learn how this compound works in the near future.

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