potent oral non-_-opioid receptor analgesic

oral activity in pain model, unknown mech.

Inspired by natural product, conolidine

Bioorg. Med. Chem., Aug. 8, 2020

Daiichi Sankyo, Tokyo, JP

Structure of DS34942424, an orally potent analgesic without mu opioid receptor agonist activity

DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able to demonstrate that the compound does not exert its…

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