potent oral non-_-opioid receptor analgesic
oral activity in pain model, unknown mech.
Inspired by natural product, conolidine
Bioorg. Med. Chem., Aug. 8, 2020
Daiichi Sankyo, Tokyo, JP
DS34942424 is a potent oral analgesic discovered using the natural product conolidine as a starting point. While the authors were able to demonstrate that the compound does not exert its…