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Dec. 10, 2021

CP-628006: A CFTR Potentiator


CFTR potentiator w/ diff. MoA from ivacaftor preclinical synergy w/ iva. on G551D-CFTR from 150k cmpd HTS British Journal of Pharmacology Pfizer, Cambridge, UK

Drug Hunter Team

The Pfizer CFTR potentiator, CP-628006 , enhances CFTR function in cystic fibrosis patient-derived airwell cells with a distinct mechanism of action from existing potentiators such as ivacaftor. It has a unique chemical structure, and in contrast to other potentiators does not seem to inhibit the channel at high concentrations of drug and [...]



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