CFTR potentiator w/ diff. MoA from ivacaftor

preclinical synergy w/ iva. on G551D-CFTR

from 150k cmpd HTS

British Journal of Pharmacology

Pfizer, Cambridge, UK

Chemical structure of molecule CP-628006

The Pfizer CFTR potentiator, CP-628006, enhances CFTR function in cystic fibrosis patient-derived airwell cells with a distinct mechanism of action from existing potentiators such as ivacaftor. It has a unique…


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