CFTR potentiator w/ diff. MoA from ivacaftor
preclinical synergy w/ iva. on G551D-CFTR
from 150k cmpd HTS
British Journal of Pharmacology
Pfizer, Cambridge, UK
CP-628006
The Pfizer CFTR potentiator, CP-628006, enhances CFTR function in cystic fibrosis patient-derived airwell cells with a distinct mechanism of action from existing potentiators such as ivacaftor. It has a unique…