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oral toll-like receptors 7/8/9 antagonist
oral efficacy in autoimmune disease models
from cell-based screen and opt.
ACS Med. Chem. Lett., Jul. 29, 2020
Bristol-Myers Squibb, Princeton, NJ
“compound 7f” is an antagonist of the endosomal TLRs 7/8/9, which induce inflammation in response to internalized single-stranded RNA or hypomethylated double-stranded DNA. Potency and selectivity within endosomal TLR’s (3,…
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