degrader with simpler CRBN warhead
BRD4 DC50 = 0.87 nM, Dmax = 99%
from structure-based design
Angewandte Chemie Int. Ed.
Saint Jude Children’s Hospital, Memphis, TN
compound 4c
The bifunctional degrader, SJ995973, was nominated by Joachim Rudolph. “Instead of the thalidomide-based cereblon binder present in the established BET degrader tool dBET1, SJ995973 uses a novel cereblon binder containing a…