degrader with simpler CRBN warhead

BRD4 DC50 = 0.87 nM, Dmax = 99%

from structure-based design

Angewandte Chemie Int. Ed.

Saint Jude Children’s Hospital, Memphis, TN

Chemical structure of molecule SJ995973 compound 4c

 The bifunctional degrader, SJ995973, was nominated by Joachim Rudolph. “Instead of the thalidomide-based cereblon binder present in the established BET degrader tool dBET1, SJ995973 uses a novel cereblon binder containing a…


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