bioavailable bicyclic macrocycle PCSK9 inh.

%F cyno = 2.9, MW 1612, preclinical

from mRNA display screen and SBDD

Journal of Medicinal Chemistry

Merck & Co.

Chemical structure of molecule "compound 44" Merck bicyclic macrocyclic peptide PCSK9 inhibitor

The Merck bicyclic macrocyclic peptide PCSK9 inhibitor, “compound 44,” is a highly potent (Ki = 0.00239 nM) and orally bioavailable (cyno %F = 2.9, t1/2 = 10 h) agent…

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