sphingosine-1-phosphate recep. mod. prodrug

for multiple sclerosis, proj. human t1/2 of 5d

from opt. of prior S1P1 modulators

ACS Med. Chem. Lett., Aug. 11, 2020

Bristol-Myers Squibb, Princeton, NJ

“compound 3d” is a prodrug which is phosphorylated in vivo to form a potent sphingosine-1-phopshate receptor modulator. BMS took two previous compounds into the clinic for MS with the…


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