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ATG7 E1 substrate-assisted covalent inhibitor
autophagy inhibition in vivo (150 mg/kg SC)
from focused HTS of adenosine sulfamates
Bioorg. Med. Chem., Aug. 4, 2020
Takeda, Cambridge, MA
“compound 37” is an inhibitor of the ATG7 E1 ligase through an interesting substrate-assisted covalent mechanism. Rather than covalently modify ATG7 directly, the molecule reacts with the E1 ligase substrate,…
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