Chemical structure of molecule compound 25 HPK1 kinase inhibitor

HPK1 kinase inhibitor

unusual P-loop-folded conformation inhibitor

from HTS + SBDD

ACS Medicinal Chemistry Letters

Genentech, South San Francisco, CA

“Compound 25,” inhibits HPK1 via a rare “P-loop folded” active site conformation. The molecule was nominated by reviewer Julien Lefranc, and structural biologist Yoana Dimitrova shares some insight here:…

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