IRE1_ kinase-binding endonuclease inhibitor

unfolded prot. response disruption for MM

from kinase library screen and SBDD

ACS Med. Chem. Lett, Oct. 16, 2020

Genentech, So. San Francisco, CA / Paraza, QC

Structure of compound 25

“compound 25” (Genentech IRE1 alpha kinase-binding endonuclease inhibitor)

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