“compound 20” is a gamma-secretase modulator (GSM) with an interesting, uncommon oxadiazine scaffold. Like many hot areas in drug discovery, the GSM area for Alzheimer’s has led to many creative chemical scaffolds. It’s always interesting to see how these new scaffolds behave. This compound demonstrates surprisingly low clearance, high [...]
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Sep. 18, 2021
Compound 20: A Gamma-Secretase Modulator With an Uncommon Oxadiazine Scaffold
"compound 20"
oral brain penetrant γ-secretase modulator oral reduction of CSF Aβ42 in model rational design from literature starting point J. Med. Chem., Aug. 13, 2020 Merck & Co., Kenilworth, NJ