oral brain penetrant _-secretase modulator
oral reduction of CSF A_42 in model
rational design from literature starting point
J. Med. Chem., Aug. 13, 2020
Merck & Co., Kenilworth, NJ
“compound 20”
“compound 20” is a gamma-secretase modulator (GSM) with an interesting, uncommon oxadiazine scaffold. Like many hot areas in drug discovery, the GSM area for Alzheimer’s has led to many creative…