oral brain penetrant _-secretase modulator

oral reduction of CSF A_42 in model

rational design from literature starting point

J. Med. Chem., Aug. 13, 2020

Merck & Co., Kenilworth, NJ

Structure of compound 20

“compound 20” is a gamma-secretase modulator (GSM) with an interesting, uncommon oxadiazine scaffold. Like many hot areas in drug discovery, the GSM area for Alzheimer’s has led to many creative…


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