NaPi2b inhibitor - Kyowa Kirin Co., Ltd.

NaPi2b inhibitor

preclinical (hyperphosphatemia)

in-house compound screen + optimization

J. Med. Chem.

Kyowa Kirin Co., Ltd.

Compound 15 is a gut-restricted inhibitor of NaPi2b, a sodium-dependent phosphate transport protein in the solute carrier (SLC) family. NaPi2b is expressed on the apical side of the small…

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