potent ghrelin receptor full agonist

for atrophy/cachexia, not advanced due to PK

from HTS and ligand-based design

J. Med. Chem., Aug. 12, 2020

Astrazeneca, Molndal, SE

“compound 12j” is a potent agonist of the ghrelin hormone receptor, activation of which stimulates growth hormone secretion and appetite among other activities. Ghrelin receptor antagonists have previously been explored…


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