potent and selective _v_5 integrin inhibitor

selective in vitro tool compound

from internal integrin library and optimization

Eur. J. Med. Chem., Aug. 2, 2020

GlaxoSmithKline, Stevenage, UK

Structure of compound 12

“compound 12” is a selective inhibitor of integrin αvβ5, a potential target for sepsis due to its potential role in regulating vascular leakage. Selectivity among integrin family members can be…


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