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Sep. 18, 2021

Compound 12: A Potent and Selective αVβ5 Integrin Inhibitor

"compound 12" (GlaxoSmithKline)

potent and selective αVβ5 integrin inhibitor selective in vitro tool compound from internal integrin library and optimization Eur. J. Med. Chem., Aug. 2, 2020 GlaxoSmithKline, Stevenage, UK

Drug Hunter Team

“compound 12” is a selective inhibitor of integrin αvβ5, a potential target for sepsis due to its potential role in regulating vascular leakage. Selectivity among integrin family members can be challenging to achieve and can have significant safety implications – hence, most integrin drugs have been selective biologics. Since the biological [...]



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