potent and selective _v_5 integrin inhibitor

selective in vitro tool compound

from internal integrin library and optimization

Eur. J. Med. Chem., Aug. 2, 2020

GlaxoSmithKline, Stevenage, UK

“compound 12” is a selective inhibitor of integrin αvβ5, a potential target for sepsis due to its potential role in regulating vascular leakage. Selectivity among integrin family members can be…


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