Structure of compound 12

selective GluN2B negative allosteric mod.

active in brain, proj. oral dose of 120 mg

from cell-based HTS and opt.

J. Med. Chem., Jul. 31, 2020

Janssen R&D, San Diego, CA

“compound 12” is a selective negative allosteric modulator of the GluN2B subunit of NDMA receptors intended for treatment of mood disorders. In this program, poor solubility and permeability were a…

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