oral PPARg phosphorylation inhibitor, partial agonist - AstraZeneca, Gothenburg, SE

oral PPARg phosphorylation inhibitor, partial agonist

efficacy in diabetic mouse model

from structure-based virtual screen

ACS Med. Chem. Lett.

AstraZeneca, Gothenburg, SE

Context. “Compound 10” (AstraZeneca) is an oral CDK5-mediated PPARγ phosphorylation inhibitor and partial PPARγ agonist being developed as an antidiabetic drug. Although widely used PPARγ agonists such as rosiglitazone…


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