CD33 splicing modulator - Pfizer Inc.

CD33 splicing modulator

preclinical (neurodegeneration)

from 3.1M cmpd phenotypic CD33 splicing screen

ACS Med. Chem. Lett.

Pfizer Inc.

compound 1 is a CD33 pre-mRNA splicing modulator that increases CD33 exon 2 skipping in cells. CD33/Siglec 3 regulates microglia activity, and genetic alterations of CD33 are associated with…


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