oral pan-TRK inhibitor

tumor regression NIH3T3/NTRK1 mice models

from in-house library screening and SBDD

J. Med. Chem.

Chugai Pharmaceutical, Shizuoka, JP

CH7057288 chemical structure oral pan-TRK inhibitor - Chugai Pharmaceutical, Shizuoka, JP

Context. CH7057288 (Chugai Pharmaceutical Co) is an oral pan-tropomyosin receptor kinase (TRK) inhibitor. Chromosomal rearrangements in the NTRK1–3 genes that encode gene fusions leading to TRK fusion proteins have…

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