oral LPA1 GPCR receptor antagonist

Ph. II candidate for IPF (60 mg BID)

from addressing tox. of prior candidate

Journal of Medicinal Chemistry

Bristol Myers Squibb, Princeton, NJ

Chemical structure of molecule BMS-986278

This month’s cover molecule, BMS-986278, is an LPA1 antagonist and oral (up to 125 mg BID) Ph. II clinical candidate for idiopathic pulmonary fibrosis (IPF) (NCT04308681). Reviewer and nominator Christian Kuttruff says: “While…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: