Chemical structure of molecule BMS-986278

oral LPA1 GPCR receptor antagonist

Ph. II candidate for IPF (60 mg BID)

from addressing tox. of prior candidate

Journal of Medicinal Chemistry

Bristol Myers Squibb, Princeton, NJ

This month’s cover molecule, BMS-986278, is an LPA1 antagonist and oral (up to 125 mg BID) Ph. II clinical candidate for idiopathic pulmonary fibrosis (IPF) (NCT04308681). Reviewer and nominator Christian Kuttruff says: “While…

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