3 minute read
Apr. 19, 2022

MS-986176/LX-9211: an Oral, CNS-Penetrable AAK1 Kinase Inhibitor to Treat Neuropathic Pain


oral CNS-penetrant AAK1 kinase inhibitor in Ph. II for neuropathic pain from high-throughput screen + opt. J. Med. Chem., March 8, 2022 Bristol-Myers Squibb, Wallingford, CT

Drug Hunter Team

Context. BMS-986176/LX-9211 (BMS) is an oral, CNS-penetrable AAK1 kinase inhibitor being developed for treatment of neuropathic pain . There are six main classes of pain medications, NSAIDs, opioids, ion channel modulators, serotonergic, monoaminergic, and GABAnergic drugs that are broadly used for pain in general, but neuropathic pain due to [...]



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