oral CNS-penetrant AAK1 kinase inhibitor - Bristol-Myers Squibb, Wallingford, CT

oral CNS-penetrant AAK1 kinase inhibitor

in Ph. II for neuropathic pain

from high-throughput screen + opt.

J. Med. Chem.

Bristol-Myers Squibb, Wallingford, CT

Context. BMS-986176/LX-9211 (BMS) is an oral, CNS-penetrable AAK1 kinase inhibitor being developed for treatment of neuropathic pain. There are six main classes of pain medications, NSAIDs, opioids, ion channel…


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