BI-3406 is a compound which binds to SOS1, preventing it from activating the oncoprotein KRAS. While inhibition of WT-KRAS and MEK alone are anticipated to be toxic, the combination of a SOS1 inhibitor with a MEK inhibitor appears to have a broader therapeutic index due to synergy in KRAS-driven tumors. A related undisclosed SOS1 inhibitor [...]
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Sep. 18, 2021
BI-3406: A Potent and Selective SOS1/KRAS Inhibitor
BI-3406
potent and selective SOS1/KRAS inhibitor related cmpd in Ph. I for KRAS+ cancers from biochemical HTS and SBDD Cancer Discovery, Aug. 19, 2020 Boehringer Ingelheim, Vienna, AT
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