oral ATM kinase inhibitor

Ph. I candidate oncology

biochem-based screen. and BBB penetration opt

J Pharmacol Exp Ther

AstraZeneca, Cambridge, UK

AZD1390 chemical structure oral ATM kinase inhibitor - AstraZeneca, Cambridge, UK

Context. AZD1390 (recently published on by University of Minnesota) is a brain-penetrating Ataxia-Telangiectasia Mutated (ATM) kinase inhibitor under development for brain tumors. The kinase, known for its critical role…


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