In 2021 Drug Hunter highlighted 168 Molecules of the Month whose structures or stories were published for the first time, or had significant disclosures of new data. Here are the top 12 Molecules of the Year nominated by readers from 2021. They were selected from tens of thousands of research articles published by leading institutions around the world. Here is the final list of candidates for 2021’s Molecule of the Year, nominated by our readers and reviewers. It's always incredibly hard to narrow down the group, and even harder to pick just one! These finalists are selected based on a range of factors, from clinical and commercial timeliness, to technological innovation, to proof-of-concept of new scientific principles.