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Dec. 16, 2021

VIP152 (BAY 1251152): a DK9 Inhibitor

VIP152 (BAY 1251152)

50x family-selective CDK9 kinase inhibitor IV agent (5-30 mg QW) in Ph. I for cancer scaffold hop from atuveciclib Journal of Medicinal Chemistry Bayer, Berlin, DE / Vincerx, Palo Alto, US

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Drug Hunter Team

The Vincerx Pharma/Bayer CDK9 inhibitor, VIP152 (BAY 1251152) , is a once-weekly (5-30 mg) IV agent in Ph. I for cancer with >50x family-selectivity . The sulfoximine-containing molecule is derived from the oral candidate atuveciclib (interestingly with opposite sulfoximine stereochemistry) and is significantly more potent under high ATP [...]

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