Chemical structure of the VIP152 (BAY 1251152) inhibitor

>50x family-selective CDK9 kinase inhibitor

IV agent (5-30 mg QW) in Ph. I for cancer

scaffold hop from atuveciclib

Journal of Medicinal Chemistry

Bayer, Berlin, DE / Vincerx, Palo Alto, US

The Vincerx Pharma/Bayer CDK9 inhibitor, VIP152 (BAY 1251152), is a once-weekly (5-30 mg) IV agent in Ph. I for cancer with >50x family-selectivity. The sulfoximine-containing molecule is derived from the oral…

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