TAK-653

potent AMPA-R potentiator w/ min. agonism

6 mg PO QD in Ph. II (withdrawn, biz decision)

from biochemical screen + opt.

Scientific Reports

Takeda Pharmaceutical, Fujisawa, JP

The Takeda AMPA-R potentiator, TAK-653, is a glutamate-dependent potentiator that exhibits minimal agonism. AMPA-R agonism is associated with seizure risk and bell-shaped dose-response effects. As reviewer Jake Schwarz notes, companies including Cortex…

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