potent AMPA-R potentiator w/ min. agonism
6 mg PO QD in Ph. II (withdrawn, biz decision)
from biochemical screen + opt.
Scientific Reports
Takeda Pharmaceutical, Fujisawa, JP
TAK-653
The Takeda AMPA-R potentiator, TAK-653, is a glutamate-dependent potentiator that exhibits minimal agonism. AMPA-R agonism is associated with seizure risk and bell-shaped dose-response effects. As reviewer Jake Schwarz notes, companies including Cortex…