< 1 minute read
Dec. 16, 2021

TAK-071: a Brain-Penetrant M1R Positive Allosteric Modulator (PAM)


low α- M1R positive allosteric modulator 7.5 mg+ PO QD in Ph. II for Parkinson’s from eval. of M1R PAMs w/ low cooperativity British Journal of Clinical Pharmacology Takeda Pharmaceutical, Cambridge, USA

Drug Hunter Team

The Takeda brain-penetrant M1R positive allosteric modulator (PAM), TAK-071, was optimized for lower cooperativity (α) with the native ligand to theoretically reduce the side effect of diarrhea from M1R activation. In animal models, higher cooperativity on M1R was associated with diarrhea, while lower cooperativity led to a wider margin. In [...]



Other molecules you may be interested in