low α- M1R positive allosteric modulator

7.5 mg+ PO QD in Ph. II for Parkinson’s

from eval. of M1R PAMs w/ low cooperativity

British Journal of Clinical Pharmacology

Takeda Pharmaceutical, Cambridge, USA

The Takeda brain-penetrant M1R positive allosteric modulator (PAM), TAK-071, was optimized for lower cooperativity (α) with the native ligand to theoretically reduce the side effect of diarrhea from M1R…


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