oral GCS inhibitor - Takeda

oral GCS inhibitor

Preclinical, neurodegeneration

scaffold hop from prev. reported GCS inhibitor

J. Med. Chem.


Context. T-690 (Takeda) is an oral GCS inhibitor that is brain-penetrant, non-basic, and non-competitive with UDP-glucose. We recently highlighted a glucosylceramide synthase (GCS, aka CGT) inhibitor in Ph. III…

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