2 minute read
Mar. 12, 2022

T-690: an oral GCS inhibitor


oral GCS inhibitor Preclinical, neurodegeneration scaffold hop from prev. reported GCS inhibitor J. Med. Chem. Takeda

Drug Hunter Team

Context. T-690 (Takeda) is an oral GCS inhibitor that is brain-penetrant, non-basic, and non-competitive with UDP-glucose. We recently highlighted a glucosylceramide synthase (GCS, aka CGT) inhibitor in Ph. III (Sanofi’s venglustat ). GCS inhibition may reduce glycosphingolipid levels downstream of its product, glucosylceramide (GlcCer). GCS [...]



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