A Next-Generation Mutant-Selective PI3Kα Allosteric Inhibitor with a Potentially Improved Safety Profile

STX-478

mutant-selective, allosteric PI3Ka inhibitor Ph. I/II for breast cancer and other solid tumors from affinity selection mass spectrometry (ASMS) screen Cancer Discov., August 2023 Scorpion Therapeutics, Boston, MA

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