5 minute read
Nov. 28, 2022

Sebetralstat: a Plasma Kallikrein (PKa) Inhibitor


oral, on-demand plasma kallikrein inhibitor Ph. III candidate for on-demand treatment of HAE attacks opt. from a known starting point J. Med. Chem. KalVista Pharmaceuticals Ltd., Salisbury, U.K.

Drug Hunter Team

Context. Sebetralstat (KalVista Pharmaceuticals) is an oral, on-demand plasma kallikrein (PKa) inhibitor intended for hereditary angioedema (HAE). As an on-demand medication, it can be administered to treat acute attacks rather than chronically to prevent attacks. Its structure was first disclosed at the ACS Spring Meeting earlier this year [...]



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