CDK inhib. and mol. glue degrader of cyclin K
selective degradation of cyclin K in cells
from characterization of 4.5k known cmpds
Nature, Jun. 3, 2020
Broad Institute / Friedrich Miescher Institute
(R)-CR8
(R)-CR8 is a known CDK inhibitor that was recently discovered to be a molecular glue-type degrader of cyclin K. A crystal structure of an E3 component-CR8-CDK12-cyclin K complex shows that…