CNS-penetrant tubulin-binder (colchicine site)

oral agent in Ph. I for leiomyosarcoma

not a P-gp substrate, formerly BMI-1 inh.

Molecular Cancer Therapeutics

PTC Therapeutics, South Plainfield, US

Chemical structure of PTC596 PTC Therapeutics oral, brain-penetrant tubulin-binding agent

The PTC Therapeutics oral, brain-penetrant tubulin-binding agent, PTC596, is in Ph. I clinical studies for advanced solid tumors (starting dose of 200 mg PO BIW). We recently highlighted encequidar, a P-gp…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: