Chemical structure of molecule MRTX1133

reversible KRASG12D inhibitor

preclinical efficacy in cancer model

from SBDD around KRASG12C inhibitor

Journal of Medicinal Chemistry

Mirati Therapeutics, San Diego, CA

MRTX1133 was nominated as December 2021’s cover molecule by reviewers Joachim Rudolph and Julien Lefranc. MRTX1133 is a non-covalent inhibitor of KRASG12D that demonstrated tumor regression in a mouse…

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