fbpx

molecules of the month

MK-5204

orally active beta-1,3-glucan synthesis inhibitor

eff. in fungal infect. model, discont. for alt.

from semisynthetic mod. of enfumafungin

Bioorg. Med. Chem. Lett., Jun. 19, 2020

Merck & Co., Kenilworth, NJ / Scynexis

MK-5204
1 min read

MK-5204 is a broad spectrum Candida antifungal agent derived from the natural product, enfumafungin. I was impressed that the molecule not only demonstrates oral efficacy but also has good oral PK in higher species (dog, cyno), given that the molecule is a large zwitterion with several very polar groups, including a primary amide, primary amine, carboxylic acid, and triazole. Development of this molecule was discontinued in favor of a further optimized analog, ibrexafungerp (MK-3118, SCY-078), currently in phase III clinical trials.


request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.


already a member? log in: