orally active beta-1,3-glucan synthesis inhibitor
eff. in fungal infect. model, discont. for alt.
from semisynthetic mod. of enfumafungin
Bioorg. Med. Chem. Lett., Jun. 19, 2020
Merck & Co., Kenilworth, NJ / Scynexis
MK-5204
MK-5204 is a broad spectrum Candida antifungal agent derived from the natural product, enfumafungin. I was impressed that the molecule not only demonstrates oral efficacy but also has good oral…