orally active beta-1,3-glucan synthesis inhibitor

eff. in fungal infect. model, discont. for alt.

from semisynthetic mod. of enfumafungin

Bioorg. Med. Chem. Lett., Jun. 19, 2020

Merck & Co., Kenilworth, NJ / Scynexis

MK-5204 is a broad spectrum Candida antifungal agent derived from the natural product, enfumafungin. I was impressed that the molecule not only demonstrates oral efficacy but also has good oral…

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