JTE-052 (delgocitinib)

topical Janus kinase (JAK) family inhibitor

approved for atopic dermatitis in JP

from scaffold hop from known JAK inhibitor

J. Med. Chem., Jun. 8, 2020

Japan Tobacco, Osaka, JP

JTE-052 (delgocitinib) is a pan-JAK kinase inhibitor approved as a topical ointment for treatment of atopic dermatitis in Japan. The compound has an interesting azetidine-containing diazaspirocycle core and a relatively…

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