topical Janus kinase (JAK) family inhibitor

approved for atopic dermatitis in JP

from scaffold hop from known JAK inhibitor

J. Med. Chem., Jun. 8, 2020

Japan Tobacco, Osaka, JP

JTE-052 (delgocitinib) is a pan-JAK kinase inhibitor approved as a topical ointment for treatment of atopic dermatitis in Japan. The compound has an interesting azetidine-containing diazaspirocycle core and a relatively…


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