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molecules of the month

JTE-052 (delgocitinib)

topical Janus kinase (JAK) family inhibitor

approved for atopic dermatitis in JP

from scaffold hop from known JAK inhibitor

J. Med. Chem., Jun. 8, 2020

Japan Tobacco, Osaka, JP

Structure of JAK inhibitor Delgocitinib
1 min read

JTE-052 (delgocitinib) is a pan-JAK kinase inhibitor approved as a topical ointment for treatment of atopic dermatitis in Japan. The compound has an interesting azetidine-containing diazaspirocycle core and a relatively high sp3-fraction for a kinase inhibitor.


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