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Sep. 18, 2021

Delgocitinib: A Topical Janus Kinase Family Inhibitor

JTE-052 (delgocitinib)

topical Janus kinase (JAK) family inhibitor approved for atopic dermatitis in JP from scaffold hop from known JAK inhibitor J. Med. Chem., Jun. 8, 2020 Japan Tobacco, Osaka, JP

Drug Hunter Team

JTE-052 (delgocitinib) is a pan-JAK kinase inhibitor approved as a topical ointment for treatment of atopic dermatitis in Japan. The compound has an interesting azetidine-containing diazaspirocycle core and a relatively high sp3-fraction for a kinase inhibitor.



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