potent, oral fusion inhibitor of RSV virus

efficacious in Ph. 2a challenge study in HV

from scaffold hop from known inhibitor

J. Med. Chem., Jun. 15, 2020

Janssen Pharmaceutica NV, Beerse, BE

JNJ-53718678 is a potent and orally available fusion inhibitor of the RSV virus, optimized from a prior oral inhibitor, BMS-433771. The prior inhibitor was challenged by moderate potency, suboptimal PK…


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