oral tissue-targeting 11β-HSD1 inhibitor

Ph. II in T2DM/obesity completed (QD)

scaffold-hopping from cortisone and prior 11β-HSD1 inh

Bioorg. Med. Chem. Lett.

Incyte Research Institute, Wilmington, DE

INCB13739 Chemical Structure, oral tissue-targeting 11β-HSD1 inhibitor - Incyte Research Institute, Wilmington, DE

Context. INCB13739 (Incyte) is an oral 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) antagonist. Inhibition of the tissue-specific generation of cortisol using agents that antagonize 11β-HSD1, the key metabolic enzyme involved in…

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