oral tissue-targeting 11β-HSD1 inhibitor
Ph. II in T2DM/obesity completed (QD)
scaffold-hopping from cortisone and prior 11β-HSD1 inh
Bioorg. Med. Chem. Lett.
Incyte Research Institute, Wilmington, DE
Context. INCB13739 (Incyte) is an oral 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) antagonist. Inhibition of the tissue-specific generation of cortisol using agents that antagonize 11β-HSD1, the key metabolic enzyme involved in…