Structure of small molecule agonist Selgantolimod

pre-systemic oral toll-like receptor 8 agonist

in multiple Ph. II studies for chron. hep. B

from optimization of lit. dual TLR7/8 agonists

J. Med. Chem., Jun. 3, 2020

Gilead Sciences, Foster City, CA

GS-9688 (selgantolimod) is a potent and selective TLR8 agonist sparing related receptor TLR7, and is intended to induce better immune responses in chronic hepatitis B. Since systemic activation of TLR8…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.