pre-systemic oral toll-like receptor 8 agonist

in multiple Ph. II studies for chron. hep. B

from optimization of lit. dual TLR7/8 agonists

J. Med. Chem., Jun. 3, 2020

Gilead Sciences, Foster City, CA

GS-9688 (selgantolimod) is a potent and selective TLR8 agonist sparing related receptor TLR7, and is intended to induce better immune responses in chronic hepatitis B. Since systemic activation of TLR8…


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