GSK3β-sparing DYRK1A kinase inhibitor

orally efficacious in proliferation model, but non-specific proliferation observed

from cellular phenotypic screen and opt.

J. Med. Chem. Feb. 20, 2020

Novartis (GNF), San Diego, CA

Structure of selective DYRK1A inhibitor GNF2133

GNF2133 (Novartis (GNF) oral in vivo GSK3-beta-sparing DYRK1A kinase inhibitor)

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