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Mar. 12, 2022

Danavorexton: a CNS-Penetrant, Injectable OX2 Agonist


injectable OX2 agonist Ph. I candidate for narcolepsy from HTS and optimization ACS Med. Chem. Lett. Takeda

Drug Hunter Team

Context. Danavorexton (Takeda, TAK-925) is a CNS-penetrant, injectable OX2 agonist. Orexin receptor (OX1/OX2) antagonists (e.g. daridorexant ) are approved for treatment of insomnia. Orexin agonism would be expected to have the opposite effect, promoting wakefulness rather than sleep, which is helpful for patients with narcolepsy (difficulty [...]



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