Chemical structure of compound 59 BMS AAK1 kinase inhibitor

brain penetrant AAK1 kinase inhibitor

efficacious in neuropathic pain model

from biochemical screen of in-house library

Journal of Medicinal Chemistry

Bristol Myers Squibb, Wallingford, US

The BMS AAK1 kinase inhibitor, compound 59, is brain-penetrant and acts on the CNS. The target was identified from a phenotypic screen of mouse knockouts, and a non-brain penetrant inhibitor…

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