brain penetrant AAK1 kinase inhibitor

efficacious in neuropathic pain model

from biochemical screen of in-house library

Journal of Medicinal Chemistry

Bristol Myers Squibb, Wallingford, US

Chemical structure of compound 59 BMS AAK1 kinase inhibitor

The BMS AAK1 kinase inhibitor, compound 59, is brain-penetrant and acts on the CNS. The target was identified from a phenotypic screen of mouse knockouts, and a non-brain penetrant inhibitor…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: