brain penetrant AAK1 kinase inhibitor
efficacious in neuropathic pain model
from biochemical screen of in-house library
Journal of Medicinal Chemistry
Bristol Myers Squibb, Wallingford, US
compound 59
The BMS AAK1 kinase inhibitor, compound 59, is brain-penetrant and acts on the CNS. The target was identified from a phenotypic screen of mouse knockouts, and a non-brain penetrant inhibitor…