Compound 4e Chemical Structure, inhaled p38α/β MAPK inhibitor - Chiesi Farmaceutici, Parma, IT

inhaled p38α/β MAPK inhibitor

effective in the rat LPS-induced lung inflamm. model

SBDD and focus on slow dissociation kinetics

J. Med. Chem.

Chiesi Farmaceutici, Parma, IT

Context. “compound 4e” (Chiesi Farmaceutici) is an inhaled p38α/β mitogen-activated protein kinase (MAPK) inhibitor being developed for lung inflammatory diseases. As a regulator of key proinflammatory mediators, p38 MAPK…

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