TNF_ allosteric inh. (asym. trimer stabilizer)

oral eff. in arthritis model similar to biologic

scaffold hop from lit. starting point + SBDD

J. Med. Chem., Dec. 1, 2020

Bristol-Myers Squibb, Princeton, NJ

Structure of compound 42

Bristol Myers Squibb (BMS) selective TNF╬▒ allosteric inhibitor

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